I've mentioned it before, but in addition to finishing some other projects, I'd like to take 4C (TSR Marvel clone) and mix it with the Black Hack.
It would use Zak's 3d20 system instead of a universal table.
The rule of Weaker/Stronger opponents would prevent situations like Aunt May punching Galactus and causing damage. (Technically possible if Galactus was completely unarmored.)
For that rule to work, this would mean, of course, that villains would have a single ranking number besides Armor and Powers.
I'd also think that traditional armor points don't work as well as treating armor as damage reduction.
There would still need to be a table for each ability or power for what 1, 2, and 3 successes would mean.