Any gamer worth his/her salt reads Jeff's Gameblog for good reason. He has some really good ideas. I was happy to discover an older post of his through a post on Herb's Places to Go, People to Be site.
In Herb's post, he draws together his recipe for an alchemical campaign. You can read the link to see his sources. Jeff's original post is inspiring in its simplicity and daunting in its execution.